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Polarographic study of zinc bound to alcohol dehydrogenase

✍ Scribed by Jan Kovář; Břestislav Brzobohatý; Marie Studničková

Publisher: Elsevier Science
Year: 1982
Tongue: English
Weight: 674 KB
Volume: 9
Category: Article
ISSN: 1567-5394
DOI: 10.1016/0302-4598(82)80023-8

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In conclusion, this total synthesis of ()-discodermolide proceeds in 27 steps and 7.7 % overall yield for the longest linear sequence starting from commercial methyl (S)-3hydroxy-2-methylpropionate. The three key subunits were synthesized efficiently using boron-mediated anti-selective aldol reactio