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Cofactor-Bound Cross-Linked Enzyme Crystals (CLEC) of Alcohol Dehydrogenase

✍ Scribed by Nancy St. Clair; Yi-Fong Wang; Alexey L. Margolin


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
111 KB
Volume
39
Category
Article
ISSN
0044-8249

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Cofactor-Bound Cross-Linked Enzyme Cryst
✍ Nancy St. Clair; Yi-Fong Wang; Alexey L. Margolin πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 104 KB

In conclusion, this total synthesis of ()-discodermolide proceeds in 27 steps and 7.7 % overall yield for the longest linear sequence starting from commercial methyl (S)-3hydroxy-2-methylpropionate. The three key subunits were synthesized efficiently using boron-mediated anti-selective aldol reactio