Cofactor-Bound Cross-Linked Enzyme Cryst
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Nancy St. Clair; Yi-Fong Wang; Alexey L. Margolin
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Article
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2000
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John Wiley and Sons
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English
β 104 KB
In conclusion, this total synthesis of ()-discodermolide proceeds in 27 steps and 7.7 % overall yield for the longest linear sequence starting from commercial methyl (S)-3hydroxy-2-methylpropionate. The three key subunits were synthesized efficiently using boron-mediated anti-selective aldol reactio