Polarographic and voltammetric behaviour of ofloxacin and its analytical application

✍ Scribed by Gerong Zhou; Jinghao Pan

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 372 KB
• Volume: 307
• Category: Article
• ISSN: 0003-2670
• DOI: 10.1016/0003-2670(95)00028-x

✦ Synopsis

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The polarographic and voltammetric behaviour of ofloxacin was studied by various electrochemical methods. A well-defined linear-sweep voltammetric peak was obtained at -1.343 V (vs. saturated calomel elctrode) in Britton-Kobinson buffer (pH 4.00). The characteristics of the peak have been examined in detail. The experimental results prove that the reduction of ofloxacin is irreversible and that the peak has adsorption characteristics. A mechanism is proposed for the reduction of the sample. The peak current (i',) is proportional to the concentration over the range 8 X 10 -4-2 X lOmY mol 1~ ' and the limit of detection is 4 X lop6 mol 1-l. A single-sweep oscillopolarographic method was developed for the determination of ofloxacin in pharmaceutical formulations. The mean recovery of ofloxacin was 101 .O% with an relative standard deviation of 2.2%.