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Polarized light imaging of white matter architecture

✍ Scribed by Luiza Larsen; Lewis D. Griffin; David GRäßel; Otto W. Witte; Hubertus Axer

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
693 KB
Volume
70
Category
Article
ISSN
1059-910X

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✦ Synopsis

Abstract

Polarized light imaging (PLI) is a method to image fiber orientation in gross histological brain sections based on the birefringent properties of the myelin sheaths. The method uses the transmission of polarized light to quantitatively estimate the fiber orientation and inclination angles at every point of the imaged section. Multiple sections can be assembled into a 3D volume, from which the 3D extent of fiber tracts can be extracted. This article describes the physical principles of PLI and describes two major applications of the method: the imaging of white matter orientation of the rat brain and the generation of fiber orientation maps of the human brain in white and gray matter. The strengths and weaknesses of the method are set out. Microsc. Res. Tech., 2007. © 2007 Wiley‐Liss, Inc.

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