Certain constitutional chromosomal abnor-0.001), but not significantly so. This finding and malities increase the risk of malignancy and/or a literature review failed to confirm an increased decrease treatment tolerance. We identified two frequency of the XYY syndrome among children patients with th
Poland's syndrome with acute lymphoblastic leukemia in an adult
โ Scribed by Parikh, P. M. ;Karandikar, S. M. ;Koppikar, S. ;Pahuja, R. ;Charak, B. S. ;Saikia, T. ;Gopal, R. ;Advani, S. H.
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 190 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0098-1532
No coin nor oath required. For personal study only.
โฆ Synopsis
W e report a patient with Poland's syndrome who developed acute lymphoblastic leukemia (ALL) at 28 years of age. This is the first time that such an association has been reported from outside the United States or in an adult. The relevant literature is reviewed.
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## Background: Loss of heterozygosity (loh) at the atm gene (mutated in ataxia telangiectasia [at] patients) and atm protein deficiency occur in 14% and 34%, respectively, of patients with chronic lymphocytic leukemia (cll). atm protein deficiency also is associated with aggressive disease and wors