Point mutations in the pre-core region of HBV in anti-HBe positive patients with chronic hepatitis and persistent HBV replication
β Scribed by Carman, W; Jeeyna, M; Karayiannis, P; Hadziyannis, S; Thomas, HC
- Book ID
- 123053621
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 47 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0168-8278
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Ninety-four patients, who were admitted with symptoms of liver disease and found to be positive for hepatitis B surface antigen and antibody to hepatitis B e antigen (anti-HBe), were examined for hepatitis B virus (HBV) DNA in serum and immunoglobulin antibody to hepatitis B core antigen and liver b
## Abstract Some chronic HBV carriers have circulating HBV DNA despite the presence of antiβHBeAg antibodies. This observation has recently been related to the presence, in the HBV preβC region, of a translational stop codon that prevents HBeAg synthesis. In the present study, we analyzed, at the n