Mutation of the core region of HBV-DNA and submassive hepatic necrosis in patients with anti-HBe-positive chronic hepatitis B
β Scribed by T. NONAKA; M. ONJI; N. HORIIKE; Y. OHTA
- Book ID
- 118704189
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 944 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0815-9319
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Some chronic HBV carriers have circulating HBV DNA despite the presence of antiβHBeAg antibodies. This observation has recently been related to the presence, in the HBV preβC region, of a translational stop codon that prevents HBeAg synthesis. In the present study, we analyzed, at the n
The core promoter region of hepatitis B virus genomes regulates transcription of the precore and pregenomic mRNAs encoding hepatitis B e antigen (HBeAg) and core antigen that contain target epitopes for cytotoxic T lymphocytes. The prevalence and clinical significance of mutations in this region wer