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Point Mutation of the RetProto-oncogene in the TT Human Medullary Thyroid Carcinoma Cell Line

✍ Scribed by F. Carlomagno; D. Salvatore; M. Santoro; V. Defranciscis; L. Quadro; L. Panariello; V. Colantuoni; A. Fusco

Book ID
115576220
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
392 KB
Volume
207
Category
Article
ISSN
0006-291X

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The gene for the alpha polypeptide chain (alpha s) of the heterotrimeric G protein Gs can be activated to the putative oncogene gsp by specific point mutations at codons 201 and 227. Such mutations have been reported in 40% of human growth hormone-secreting pituitary adenomas and in a single autonom