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The cholecystokinin2-receptor mediates calcitonin secretion, gene expression, and proliferation in the human medullary thyroid carcinoma cell line, TT

✍ Scribed by Michael Bläker; Philomena Arrenberg; Inke Stange; Martina Schulz; Sylvia Burghardt; Hanna Michaelis; Andrea Pace; Heiner Greten; Tammo von Schrenck; Andreas de Weerth


Book ID
116857397
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
271 KB
Volume
118
Category
Article
ISSN
0167-0115

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Human A431 carcinoma cell line is known to have 30 fold amplified epidermal growth factor receptor (EGF-R) gene. We have studied the effect of steroid hormone dexamethasone (DEX) and protein synthesis inhibitor cycloheximide (CHX) on the expression of EGF-R gene in this cell line. DEX treatment and