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Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay

✍ Scribed by Veena Prasad; Asish Ray Chaudhuri; Matthew Curcio; Isao Tomita; Fukutaro Mizuhashi; Kyoji Murata; Richard F. Ludueña


Book ID
105606358
Publisher
Springer
Year
1998
Tongue
English
Weight
611 KB
Volume
17
Category
Article
ISSN
1573-4943

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Diethylstilbestrol is a drug used to treat prostate cancer. It is thought to bind to tubulin, the subunit protein of microtubules, at the colchicine-binding site. We examined its interaction with tubulin in more detail. Diethylstilbestrol inhibits microtubule assembly, and seems to do so more effect