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PNL2 melanocytic marker in immunohistochemical evaluation of primary mucosal melanoma of the head and neck

✍ Scribed by Luc G. Morris; Yong Hannah Wen; Daisuke Nonaka; Mark D. DeLacure; David I. Kutler; Youming Huan; Beverly Y. Wang

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
315 KB
Volume
30
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background

Histologic diagnosis of mucosal melanoma of the head and neck is difficult, requiring immunohistochemical stains which are less reliable than in cutaneous lesions. PNL‐2 is a novel marker that has not been examined in mucosal melanoma.

Methods

Nine formalin‐fixed tissue sections of mucosal melanoma were stained with PNL‐2, human melanoma black (HMB)‐45, Melan‐A, S‐100, and microphthalmia transcription factor (MITF).

Results

Disease in all 9 patients arose from the sinonasal mucosa. Rates of diffuse positive staining with the 4 stains were PNL‐2 (77.8%), HMB‐45 (77.8%), Melan‐A (50%), S‐100 (87.5%), and MITF (40%). In 3 patients, PNL2 staining was superior to Melan‐A or MITF.

Conclusion

We report the first characterization of PNL‐2 staining in head and neck mucosal melanoma. PNL‐2 demonstrates high sensitivity for mucosal melanoma, likely superior to Melan‐A and MITF, and comparable to HMB‐45, with specificity superior to S‐100. We advocate inclusion of PNL2 as an important adjunctive marker in the evaluation of these lesions. © 2008 Wiley Periodicals, Inc. Head Neck, 2008

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