✦ LIBER ✦

Accuracy of positron emission tomography in the evaluation of patients treated with chemoradiotherapy for mucosal head and neck cancer

✍ Scribed by Richard C. W. Martin; Michael Fulham; Kerwin F. Shannon; Ceri Hughes; Kan Gao; Chris Milross; Mo Mo Tin; Michael Jackson; Anthony Clifford; Michael J. Boyer; Christopher J. O'Brien

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 109 KB
Volume: 31
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.20962

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

The aim of this study was to evaluate the accuracy of positron emission tomography (PET) in assessing the patients treated with primary chemoradiotherapy for mucosal carcinoma of the head and neck.

Methods

A retrospective review of patients with biopsy‐proven cancer of mucosal head and neck sites receiving chemoradiotherapy with curative intent was undertaken.

Results

Seventy‐eight patients met the study criteria. Staging PET identified unsuspected distant metastatic disease in 11% of patients. Sixty‐one patients (78%) had a complete metabolic response on PET, with 17 showing residual disease. Sensitivity of PET was 82% (positive predictive value: 82%) and specificity was 95% (negative predictive value: 95%). Accuracy of PET response was significantly better than clinical assessment and conventional imaging (p < .002, p < .001, respectively).

Conclusion

PET has been found to be significantly better than clinical examination or conventional imaging in restaging patients after chemoradiotherapy. Patients with a complete response on posttreatment PET have a significant survival advantage and can be safely observed. © 2008 Wiley Periodicals, Inc. Head Neck, 2009

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