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PMEPA1-AR DEGRADATION PATHWAY: A NEW MECHANISM FOR THE REGULATION OF ANDROGEN RECEPTOR IN PROSTATE CANCER

✍ Scribed by Raymundo, Eliza; Hongyun, Li; Xu, Linda; Masuda, Katsuaki; McLeod, David G; Dobi, Albert; Srivastava, Shiv

Book ID
122447127
Publisher
Lippincott Williams and Wilkins
Year
2009
Tongue
English
Weight
46 KB
Volume
181
Category
Article
ISSN
0022-5347

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## Abstract Androgen receptor (AR) mutations that modify both the ligand binding and the transactivation capacities of the AR represent one of the mechanisms involved in the transition of prostate cancer (PCa) from androgen‐dependent to androgen‐independent growth. We use a yeast‐based functional a