Platinum(II)-catalyzed intramolecular cyclization of alkynylbenzonitriles: synthesis of 1-alkoxyisoquinolines and isoquinolones

✍ Scribed by Jim Li; Lijing Chen; Elbert Chin; Alfred S. Lui; Hasim Zecic

• Book ID: 104098407
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 250 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.09.136

✦ Synopsis

A facile synthesis of a series of 1-alkoxyisoquinolines and (2H)-isoquinolones by an intramolecular 6endo-dig cyclization of ortho-alkynylbenzonitriles in the presence of a catalytic amount of hydrido(dimethylphosphinous acid-jP)[hydrogen bis(dimethylphosphinito-jP)]platinum(II) in various alcohols at 65-90 °C is described for the first time.