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Total synthesis of SS20846A via intramolecular Pd(II)-catalyzed cyclization

โœ Scribed by Hajime Yokoyama; Kumiko Otaya; Seiji Yamaguchi; Yoshiro Hirai


Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
160 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


A stereoselective total synthesis of SS20846A was efficiently accomplished by means of an intramolecular palladium(ll)-catalyzed cyclization.


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Catalytic amounts of Pd(OAc)2 in the presence of c-Bu4NC1, OMF and an appropriate Et3N) cyclize nitrogen-containing o-lodoaryl alkenes to indoles, quinolines, isoquinolines and isoquTnolones in short reaction times, under mild temperatures, and in high yields. Transition metal reagents have proven h