Platelets, platelet-derived growth factor and arteriosclerosis
β Scribed by H. R. Baumgartner; M. Hosang
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 650 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1420-682X
No coin nor oath required. For personal study only.
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Platelet-derived endothelial cell growth factor (PD-ECGF) is a 45 kDa single chain polypeptide which stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo. Analysis of a full length PD-ECGF cDNA revealed an open reading frame coding for 482 amino acids without homology
Platelet-derived growth factor (PDGF) is a 30 kDa protein consisting of disulfide-bonded dimers of Aand B-chains. PDGF receptors are of two types, a-and @-receptors, which are members of the protein-tyrosine kinase family of receptors. The receptors are activated by ligand-induced dimerization, wher