Platelet-derived endothelial cell growth factor (PD-ECGF) is a 45 kDa single chain polypeptide which stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo. Analysis of a full length PD-ECGF cDNA revealed an open reading frame coding for 482 amino acids without homology
Platelet-derived growth factor.
β Scribed by W. Meyer-Ingold; W. Eichner
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 544 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1065-6995
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Platelet-derived growth factor (PDGF) is a potent activator for cells of mesenchymal origin. PDGF stimulates chemotaxis, proliferation, and new gene expression in monocytes-macrophages and fibroblasts in vitro, cell types considered essential for tissue repair. Therefore, we analyzed the influence o