Platelets enhance endotoxin-induced monocyte tissue factor (TF) activity in the horse
β Scribed by A.L. Ouellette; R.J. Evans; M.F. Heath
- Book ID
- 116874004
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 193 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0034-5288
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Background: Monocytic tissue factor (TF), an initiator of extrinsic blood coagulation, is often activated under various inΒ―ammatory conditions including endotoxemia. This activation could be a contributing factor to the manifestation of disseminated intravascular coagulation following septic shock.
Our previous study has reported that ethanol (ETOH) partially inhibited the endotoxin (LPS)-induced tissue factor (TF)-activation in monocytes including blood peripheral monocytes as well as cultured leukemic U937 and THP-1 cells. The present study shows a strong correlation r 0Γ92; p `0Γ01 between