Platelet-tumor cell interaction: effect of prostacyclin and a synthetic analog on metastasis formation

✍ Scribed by V. Costantini; P. Fuschiotti; M. Allegrucci; G. Agnelli; G. G. Nenci; M. C. Fioretti

• Book ID: 104684565
• Publisher: Springer
• Year: 1988
• Tongue: English
• Weight: 469 KB
• Volume: 22
• Category: Article
• ISSN: 0344-5704
• DOI: 10.1007/bf00254233

✦ Synopsis

The antimetastatic effect of the antithrombotic agents exogenous prostacyclin (PGI2) and a synthetic analog, Iloprost, on experimental metastasis formation was studied by injecting BL6 melanoma cells into C57BL/6 mice. Suitable in vivo treatment conditions were selected according to the known properties of the two drugs, including their pharmacokinetics. Iloprost showed a greater ability to inhibit platelet aggregation induced by BL6 melanoma cells. PGI2 displayed a limited antimetastatic activity, largely dependent on the tumor cell load and treatment schedule. Iloprost showed a far superior activity, its antimetastatic effect lasting longer and remaining detectable up to 6 h after tumor cell inoculation. The present data complex provides further support to the concept of a crucial role for platelet-tumor cell interaction in the process of metastasis formation.