Tumor cell locomotion—a factor in metastasis formation? influence of cytochalasin b on a tumor dissemination pattern
✍ Scribed by B. Hagmar; W. Ryd
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- French
- Weight
- 384 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
The influence of Cytochalasin B (CB) on TA3 ascites tumor cells was studied in vivo in order to assess whether CB‐induced cell paralysis would affect the transplantation behavior of the cells and in particular tumor distribution after IV cell infusion (“experimental metastases”). Tumor cell pre‐treatment with CB (1 μg/ml) did not alter the SC or IV transplantability of TA3 cells. Pre‐treatment with 10 μg/ml CB, in contrast, consistently increased the incidence and number of extra‐pulmonary tumor takes from IV transfused cells. The amount of pulmonary tumors was not significantly altered. SC transplantability was not affected by 10 μg/ml CB. The importance of cell mobility and cell surface topography for tumor cell nidation in vessels is discussed.