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Platelet derived growth factor (PDGF) is a chemoattractant for human malignant mesothelioma cells

✍ Scribed by Klominek, J.; Baskin, B.; Hauzenberger, D.


Book ID
122965380
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
284 KB
Volume
15
Category
Article
ISSN
0169-5002

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## Abstract In previous experiments (Grotendorst et al, 1981), we showed that platelet‐derived growth factor promotes the migration of smooth muscle cells in vitro. Using a β€œcheckerboard” analysis, we now establish that platelet‐derived growth factor (PDGF) acts as a true chemoattractant for cultur

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Tumor cells may stimulate their own proliferation through an autocrine mechanism by simultaneously producing growth factors and growth factor receptors. We now report that numerous human tumor-derived cell lines simultaneously express the genes for platelet-derived growth factor (PDGF) A and B chain