Negative growth regulators such as the transforming growth factor beta (TGF-P) family appear to be important inhibitors in most tissue types. However, inhibition of DNA synthesis and cell proliferation is frequently lost during malignant transformation, and in some cases, tumor cell proliferation is
Platelet-derived growth factor mediated altered expression and regulation of ornithine decarboxylase in H-ras-transformed cell lines
β Scribed by Daniel Voskas; Michael Kim; Robert A.R Hurta
- Book ID
- 114283569
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 245 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0898-6568
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## Abstract Mammalian Sβadenosylmethionine decarboxylase (SAMDC) is a regulatory activity, which is involved in the biosynthesis of polyamines. The polyamines, namely putrescine, spermidine, and spermine, are essential for mammalian cell proliferation. SAMDC expression was examined in a Hβras trans
We have tested the hypothesis that H-ras transformed cells contain alterations in signal pathways important in controlling the expression of ornithine decarboxylase (ODC), the highly regulated rate-limiting activity in the biosynthesis of poly-