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Platelet-derived growth factor: Isoform-specific signalling via heterodimeric or homodimeric receptor complexes

✍ Scribed by Heldin, Carl-Henrik; Östman, Arne; Eriksson, Anders; Siegbahn, Agneta; Claesson-Welsh, Lena; Westermark, Bengt


Book ID
109882309
Publisher
Nature Publishing Group
Year
1992
Tongue
English
Weight
472 KB
Volume
41
Category
Article
ISSN
0085-2538

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Relative binding and biochemical effects
✍ Michael Centrella; Thomas L. McCarthy; William F. Kusmik; Ernesto Canalis 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 835 KB

Platelet-derived growth factor (PDGF) exists as a homodimer or a heterodimer comprising either PDGF-A or PDGF-B subunits, and each isoform occurs in various tissues, including bone. Although the stimulatory effects of PDGF-BB have been studied in cultures of bone cells and intact bone fragments, the