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Peptides derived from specific interaction sites of the fibroblast growth factor 2 – FGF receptor complexes induce receptor activation and signaling

✍ Scribed by Valentina Manfè; Artur Kochoyan; Elisabeth Bock; Vladimir Berezin


Book ID
111183981
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
806 KB
Volume
114
Category
Article
ISSN
0022-3042

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## Abstract Activation of fibroblast growth factor (FGF) receptors (FGFRs) both by FGFs and by the neural cell adhesion molecule (NCAM) is crucial in the development and function of the nervous system. We found that FGFR substrate 2α (FRS2α), Src homologous and collagen A (ShcA), and phospholipase‐