Platelet-derived growth factor (PDGF) is a 30 kDa protein consisting of disulfide-bonded dimers of Aand B-chains. PDGF receptors are of two types, a-and @-receptors, which are members of the protein-tyrosine kinase family of receptors. The receptors are activated by ligand-induced dimerization, wher
Platelet-derived growth factor in human brain tumors
β Scribed by Matthias Kirsch; John C. Wilson; and Peter Black
- Book ID
- 110230034
- Publisher
- Springer US
- Year
- 1997
- Tongue
- English
- Weight
- 95 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0167-594X
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Tumor cells may stimulate their own proliferation through an autocrine mechanism by simultaneously producing growth factors and growth factor receptors. We now report that numerous human tumor-derived cell lines simultaneously express the genes for platelet-derived growth factor (PDGF) A and B chain
In human gliomas, platelet-derived growth factor (PDGF) ligand and receptor mRNA are often co-expressed, which suggests the presence of an autocrine loop. To further investigate the significance of PDGF stimulation in brain tumors, we used a previously developed mouse tumor model, in which malignant