MBA-2, bone marrow-derived endothelial stromal cells, express platelet-derived growth factor (PDGF) A and B chain mRNAs and secrete PDCF activity that is induced by TGF-beta. Either chain of the PDGF molecule could modulate hematopoiesis and stromal cell growth. lntracellular pathways that regulate
Platelet-derived growth factor B-chain gene expression in mesangial cells: Effect of phorbol ester on gene transcription and mRNA stability
β Scribed by Basant Bhandari; Kathleen Woodruff; Hanna E. Abboud
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 886 KB
- Volume
- 140
- Category
- Article
- ISSN
- 0300-8177
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The genes for platelet-derived growth factor (PDGF) A and PDGF B chains are expressed in a variety of biological situations. Active PDGF consists of two distinct but homologous polypeptide chains, PDGF A and PDGF B, which are found as heterodimers or homodimers. We report a novel situation in which
The pathogenesis of glornerular scarring i s multifactional; recent evidence suggests that transforming growth factor P (TGFP), a pleiotropic cicatricial mediator, may promote mesangial sclerosis by enhancing the production of extracellular matrix proteins. We studied the effect of TGFPl and TFGP2 o