Platelet-derived growth factor A and B chains and the α and β receptors in prostatic intraepithelial neoplasia

✍ Scribed by Fudge, Kim; Bostwick, David G.; Stearns, Mark E.

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 443 KB
• Volume: 29
• Category: Article
• ISSN: 0270-4137
• DOI: 10.1002/(sici)1097-0045(199611)29:5<282::aid-pros2>3.0.co;2-c

✦ Synopsis

BACKGROUND. The objective of this study was to evaluate the expression of plateletderived growth factor (PDGF A, PDGF B) and their receptors (PDGF a, PDGF p) in prostatic intraepithelial neoplasia (PIN) and adenocarcinoma.

METHODS.

Peroxidase-antiperoxidase immunoperoxidase labeling was used to detect the extent of antibody labeling in 29 different high grade PIN specimens.

Results

. PDGF A and PDGF a were uniformly expressed in glandular epithelial and stromal cells, whereas PDGF B was not expressed by either tissue. However, PDGF p was lightly expressed in a uniform manner by both the glandular epithelial and stromal cells. CONCLUSIONS. The data suggest that an autocrine loop may exist i n which the epithelial cells of high-grade PIN express PDGF AA and PDGF a to modulate growth of precancerous lesions.