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Plasminogen activator inhibitor type 1 is a potential target in renal fibrogenesis

✍ Scribed by Rerolle, Jean-Philippe; Hertig, Alexandre; Nguyen, Genevieve; Sraer, Jean-Daniel; Rondeau, Eric P.

Book ID
109065160
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
402 KB
Volume
58
Category
Article
ISSN
0085-2538

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TYPE-1 PLASMINOGEN ACTIVATOR INHIBITOR I
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✍ WAGNER, STEPHAN N.; ATKINSON, MICHAEL J.; THANNER, STEPHANIE; SCHMITT, MANFRED; πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 597 KB

In experimental models, plasminogen activator-mediated degradation of the extracellular matrix is inhibited by type-1 plasminogen activator inhibitor (PAI-1). PA14 has also been shown to protect tumour stromal tissue from autoproteolytic activities and may thus substantially promote tumour growth an