Plasminogen activator inhibitor type 1 in adults with Down syndrome and protection against macrovascular disease
β Scribed by William E Hopkins; Naomi K Fukagawa; Burton E Sobel; David J Schneider
- Book ID
- 113981206
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 157 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0002-9149
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We previously reported that plasminogen activator inhibitor type-1 (PAI-1) mRNA was present at higher steady-state levels in prematurely senescent fibroblasts derived from a subject with Werner syndrome (WS) compared to early passage
## Objective: To investigate the relationship between the 4g/5g polymorphism of the type 1 plasminogen activator inhibitor (pai-1) gene and thrombotic manifestations in patients with antiphospholipid syndrome (aps). ## Methods: We studied a total of 247 patients included in the following 4 groups