The type-1 inhibitor of plasminogen activator (PAI-1) is a major physiologic regulator of pericellular proteolytic activity and, as such, influences matrix integrity, cell-to-substrate adhesion, and cellular proliferation. Excessive accumulation of both PAI-1 mRNA and protein correlates with the pro
Overexpression of plasminogen activator inhibitor type-1 in senescent fibroblasts from normal subjects and those with Werner syndrome
β Scribed by Dr. Samuel Goldstein; Elena J. Moerman; Satoshi Fujii; Burton E. Sobel
- Book ID
- 102886442
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 990 KB
- Volume
- 161
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
β¦ Synopsis
We previously reported that plasminogen activator inhibitor type-1 (PAI-1) mRNA was present at higher steady-state levels in prematurely senescent fibroblasts derived from a subject with Werner syndrome (WS) compared to early passage
π SIMILAR VOLUMES
## Objective: To investigate the relationship between the 4g/5g polymorphism of the type 1 plasminogen activator inhibitor (pai-1) gene and thrombotic manifestations in patients with antiphospholipid syndrome (aps). ## Methods: We studied a total of 247 patients included in the following 4 groups