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Plasmalemmal V-H+-ATPases regulate intracellular pH in human lung microvascular endothelial cells

✍ Scribed by José D. Rojas; Souad R. Sennoune; Debasish Maiti; Gloria M. Martı́nez; Karina Bakunts; Donald E. Wesson; Raul Martı́nez-Zaguilán

Book ID
116288796
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
422 KB
Volume
320
Category
Article
ISSN
0006-291X

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## Abstract Angiogenesis requires invasion of extracellular matrix (ECM) proteins by endothelial cells and occurs in hypoxic and acidic environments that are not conducive for cell growth and survival. We hypothesize that angiogenic cells must exhibit a unique system to regulate their cytosolic pH