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Intracellular pH regulation in U937 human monocytes: roles of V-ATPase and Na+/H+ exchange

✍ Scribed by Thomas A. Heming; Akhil Bidani


Book ID
117850931
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
120 KB
Volume
207
Category
Article
ISSN
0171-2985

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Two distinct mechanisms have been shown to mediate cytoplasmic p H (pH,) recovery in acid-loaded peritoneal macrophages (M+s): Na+/H+ exchange and H + extrusion by vacuolar-type (V-type) H+ ATPases. The present studies examined the relative roles of these two systems in maintaining pH, and cell func