Plasma prostaglandins in hypercalcemic patients with neoplastic disease

✍ Scribed by L. M. Demers; J. C. Allegra; H. A. Harvey; A. Lipton; J. R. Luderer; R. Mortel; D. E. Brenner

• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: English
• Weight: 337 KB
• Volume: 39
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197704)39:4<1559::aid-cncr2820390430>3.0.co;2-3

✦ Synopsis

Peripheral plasma prostaglandin E (PGE) determinations were performed on a series of 79 patients with solid tumor neoplasms and correlated with their serum calcium levels. Fourteen patients were hypercalcemic and 11 of these had significant elevations in circulating plasma PGE. Ten of the hypercalcemic group had extensive metastases to bone. These findings support the recently developed hypothesis that prostaglandins are causally related to the genesis of hypercalcemia in malignancy. Cancer 39:1559-1562, 1977. ROSTAGLANDINS HAVE RECENTLY BEEN IMPLI-P cated in the pathogenesis of hypercalcemia associated with neoplastic disease. Since the report by Tashjian et al. ' * implicating prostaglan-From the Divisions of Oncology*, Clinical Pathology: and Gynecologic Oncology,