Plasma phospholipids n-3 polyunsaturated fatty acid is associated with metabolic syndrome

✍ Scribed by Tao Huang; Subhachai Bhulaidok; Zhenzhen Cai; Tongcheng Xu; Fang Xu; Mark L. Wahlqvist; Duo Li

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 167 KB
• Volume: 54
• Category: Article
• ISSN: 1613-4125
• DOI: 10.1002/mnfr.201000025

✦ Synopsis

Abstract

The relationship between n‐3 PUFA and metabolic syndrome (MS) is not clear. The aim of this study was to examine relationships between plasma phospholipids (PL) n‐3 PUFA and MS in Chinese subjects. Nine hundred and twenty‐nine subjects were recruited in Hangzhou, China. Two hundred and ten (183 males, 27 females) with MS and 719 (545 males, 174 females) healthy subjects were identified in this cross‐sectional study. The prevalence of MS in females (24.56%) was significantly higher than that in males (10.04%) in this population. Total PUFA (p<0.001), n‐3 PUFA (p<0.001), and n‐3:n‐6 (p<0.001) were significantly lower in MS subjects compared to healthy subjects. Plasma phospholipid (PL), n‐3 PUFA was significantly inversely associated with MS (p=0.013). In addition, subjects with high levels of PL total fatty acids (FA) had a more than threefold higher likelihood of MS (OR=3.44, 95% CI=1.60–7.39) than the subjects with low levels of PL total FA. Our results suggest that plasma PL n‐3 PUFA was significantly inversely associated with MS, while high total FA were positively associated with MS in Chinese.