Increased plasma n-3 polyunsaturated fatty acid is associated with improved insulin sensitivity in type 2 diabetes in China
✍ Scribed by Tao Huang; Mark L. Wahlqvist; Tongcheng Xu; Amei Xu; Aizhen Zhang; Duo Li
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 188 KB
- Volume
- 54
- Category
- Article
- ISSN
- 1613-4125
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✦ Synopsis
Abstract
Increased tissue n‐3 polyunsaturated fatty acid (PUFA) is associated with improved insulin sensitivity in type 2 diabetes. However, this relationship among Chinese is not clear. To investigate the relationship between plasma phospholipids (PL) fatty acid composition and insulin resistance (IR) in type 2 diabetes mellitus, 186 type 2 diabetes and 180 healthy subjects were studied in this case‐control study. In the sex, age and BMI controlled partial correlation, homeostasis model assessment (HOMA)‐IR and blood glucose was significantly negatively correlated with plasma PL n‐3 PUFA, 20:5n‐3 and ratio of n‐3:n‐6 (p<0.01), and positively correlated with n‐6 PUFA (p<0.001) and saturated fatty acid (p<0.05) in the diabetes patients. PL 22:6n‐3 was also significantly negatively correlated with HOMA‐IR (p<0.01), but not with blood glucose. Fasting insulin was significantly negatively correlated with plasma PL n‐3 PUFA, 20:5n‐3, 22:6n‐3 and ratio of n‐3:n‐6 (p<0.01). The 18:3n‐3 was not associated with HOMA‐IR and fasting insulin. The results suggested that increased plasma PL n‐3 PUFA, 20:5n‐3, 22:6n‐3 and ratio of n‐3:n‐6 PUFA was associated with decreased HOMA‐IR in type 2 diabetes. Increased plasma PL n‐3 PUFA improves insulin sensitivity in type 2 diabetes.