## Abstract Recent epidemiological studies have shown that high serum levels of insulinโlike growth factorโI (IGFโI) are associated with an increased risk of lung, colon, breast and prostate cancer. Since very few studies have addressed the role of serum levels of IGFโI in the development of pancre
Plasma insulin-like growth factor-1 and binding protein-3 and subsequent risk of prostate cancer in the PSA era
โ Scribed by Elizabeth A. Platz; Michael N. Pollak; Michael F. Leitzmann; Meir J. Stampfer; Walter C. Willett; Edward Giovannucci
- Publisher
- Springer Netherlands
- Year
- 2005
- Tongue
- English
- Weight
- 186 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0957-5243
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The mitogenic effects of insulin-like growth factors (IGFs) are regulated by a family of insulin-like growth factor binding proteins (IGFBPs). One member of this family, IGFBP-3, mediates the growth-inhibitory and apoptosis-inducing effects of a number of growth factors and hormones such as transfor
## Abstract We investigated whether circulating insulinโlike growth factorโI (IGFโI) and insulinโlike growth factor binding proteinโ3 (IGFBPโ3) levels are associated with the risk of fibrocystic breast conditions (FBC), in a caseโcontrol study nested within a randomized trial of breast selfโexamina