𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Insulin-like growth factor-I, insulin-like growth factor binding protein-3 and the risk of fibrocystic breast conditions among Chinese women

✍ Scribed by Chu Chen; Jennifer A. Doherty; S. Kay Lewis; Roberta M. Ray; Dao Li Gao; Helge Stalsberg; Ziding Feng; David B. Thomas

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
94 KB
Volume
118
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We investigated whether circulating insulin‐like growth factor‐I (IGF‐I) and insulin‐like growth factor binding protein‐3 (IGFBP‐3) levels are associated with the risk of fibrocystic breast conditions (FBC), in a case‐control study nested within a randomized trial of breast self‐examination conducted in Shanghai, China. Participants were enrolled during 1989–1991 and were followed over 10 years for the development of breast diseases. Controls (n = 897) were frequency‐matched by age to cases (n = 451), who were diagnosed with FBC between 1995 and 2000. Circulating IGF‐I and IGFBP‐3 levels and their molar ratio were positively associated with risk of FBC. The odds ratios (ORs) and 95% confidence intervals (CI) for the upper fourth of the distribution compared to the lowest fourth for IGF‐I, IGFBP3 and their molar ratio were 3.02 (2.02–4.52), 1.92 (1.37–2.71) and 2.26 (1.52–3.36), respectively. The strength of the association between IGF‐I levels and FBC was attenuated after adjustment for IGFBP‐3 and that for IGFBP‐3 was largely eliminated after adjustment for IGF‐I. Increasing levels of IGF‐I were particularly associated with increasing risk of FBC with proliferative elements (ORs and 95% CIs for the 2nd, 3rd and upper fourth of the distribution of IGF‐I: 3.13 (1.50–6.53), 4.57 (2.22–9.39) and 6.30 (3.08–12.89), compared with the lowest fourth. Our results suggest that elevated levels of IGF‐I may contribute to the development of FBC. © 2005 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Serum insulin-like growth factor-I, insu
Serum insulin-like growth factor-I, insulin-like growth factor binding protein-3, and the risk of pancreatic cancer death
✍ Yingsong Lin; Akiko Tamakoshi; Shogo Kikuchi; Kiyoko Yagyu; Yuki Obata; Teruo Is 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 75 KB 👁 1 views

## Abstract Recent epidemiological studies have shown that high serum levels of insulin‐like growth factor‐I (IGF‐I) are associated with an increased risk of lung, colon, breast and prostate cancer. Since very few studies have addressed the role of serum levels of IGF‐I in the development of pancre

Insulin-like growth factor-I gene polymo
Insulin-like growth factor-I gene polymorphism and breast cancer risk in Chinese women
✍ Wanqing Wen; Yu-Tang Gao; Xiao-Ou Shu; Herbert Yu; Qiuyin Cai; Jeffrey R. Smith; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 86 KB 👁 1 views

## Abstract The evidence that high circulating levels of insulin‐like growth factor‐I (IGF‐I) are associated with an increased risk of breast cancer among premenopausal women lends credence to the hypothesis that genetic polymorphisms in the __IGF‐I__ gene may be involved in the disease. A populati

Insulin-like growth factor–binding prote
Insulin-like growth factor–binding protein-3 and breast cancer survival
✍ He Yu; Michael A. Levesque; M. Javad Khosravi; Anastasia Papanastasiou-Diamandi; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 65 KB 👁 2 views

Insulin-like growth factors (IGFs) are potent mitogens involved in the regulation of cell proliferation and apoptosis. The action of IGFs is mediated through a specific cell membrane receptor (IGF-IR), and the interactions between IGFs and this receptor are regulated by IGF-binding proteins (IGFBPs)