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Insulin-like growth factor-I gene polymorphism and breast cancer risk in Chinese women

✍ Scribed by Wanqing Wen; Yu-Tang Gao; Xiao-Ou Shu; Herbert Yu; Qiuyin Cai; Jeffrey R. Smith; Wei Zheng

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
86 KB
Volume
113
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The evidence that high circulating levels of insulin‐like growth factor‐I (IGF‐I) are associated with an increased risk of breast cancer among premenopausal women lends credence to the hypothesis that genetic polymorphisms in the IGF‐I gene may be involved in the disease. A population‐based case‐control study was conducted to assess the association of IGF‐I gene polymorphisms [(CA)n repeats in the promoter region] with breast cancer risk and plasma IGF‐I level in Chinese women. The study included 1,041 incident breast cancer cases diagnosed from August 1996 through March 1998 in Shanghai and 1,086 randomly selected, age frequency‐matched controls from the general population. Although no relation between plasma IGF‐I levels and IGF‐I genotypes was found, women who carried the genotypes containing the (CA)17 or (CA)19 allele were associated with a significantly decreased (OR=0.80, 95% CI: 0.64–1.00) or increased (OR=1.23, 95% CI: 1.04–1.47) risk of breast cancer, respectively, and women who carried the genotypes containing any of the 4 rare alleles, (CA)11, (CA)13, (CA)16 and (CA)23, were associated with a nonsignificantly increased risk of breast cancer (OR=1.92, 95% CI: 0.92–4.02) compared to those who did not carry the specific alleles. The associations with the (CA)17 or (CA)19 allele were predominantly present among premenopausal women and in a dose‐response manner. The meta‐analysis results indicated that IGF‐I genotypes containing the (CA)19 were consistently associated with increased risk of breast cancer across studies (overall OR=1.22, 95% CI: 1.06–1.41, p for heterogeneity test=0.524). The findings of this study support the hypothesis that IGF‐I gene polymorphisms may be a significant genetic factor for breast cancer susceptibility.

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