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Plasma concentrations of temazepam, a 3-hydroxy benzodiazepine, determined by electron-capture gas—liquid chromatography

✍ Scribed by Marcia Divoll; David J. Greenblatt

Book ID
108447958
Publisher
Elsevier Science
Year
1981
Weight
266 KB
Volume
222
Category
Article
ISSN
0378-4347

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Determination of midazolam and its α-hyd
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✍ Heizmann, P. ;von Alten, R. 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB 👁 1 views

## Abstract A sensitive GC‐ECD assay has been developed for the simultaneous determination of midazolam (I) and its α‐hydroxy metabolite (II) in plasma. The assay involves extraction of both compounds into ether at alkaline pH (pH 12), followed by silylation of the α‐hydroxy metabolite with N,O‐bis