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Plasma and tissue concentrations of hycanthone in the mouse determined by reversed-phase high-performance liquid chromatography

✍ Scribed by Edwin D.W. Moore; Garth Powis

Book ID
108448155
Publisher
Elsevier Science
Year
1980
Weight
399 KB
Volume
183
Category
Article
ISSN
0378-4347

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## Abstract A sensitive and selective reversed‐phase high‐performance liquid chromatographic (HPLC) assay has been developed and validated for quantification of total topotecan in human and mouse plasma and in mouse tissue samples. Isocratic separation was achieved on a Zorbax SB‐C~18~ column and t