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Determination of paclitaxel and metabolites in mouse plasma, tissues, urine and faeces by semi-automated reversed-phase high-performance liquid chromatography

✍ Scribed by Alexander Sparreboom; Olaf van Tellingen; Willem J. Noojien; Jos H. Beijnen

Publisher
Elsevier Science
Year
1995
Weight
605 KB
Volume
664
Category
Article
ISSN
0378-4347

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## Abstract A sensitive and selective reversed‐phase high‐performance liquid chromatographic (HPLC) assay has been developed and validated for quantification of total topotecan in human and mouse plasma and in mouse tissue samples. Isocratic separation was achieved on a Zorbax SB‐C~18~ column and t