The purpose of the present study was to determine the interaction e †ect of starch and fat of such products over blood parameters (cholesterol, triglycerides), and to evaluate starch and fat digestibility. Experiments were carried out in eight groups of Sprague-Dawley rats that were under the following diets : four of the groups were fed with a mix of 14% palm oil and 58% of each one of the starches (rice, corn, manioc and green plantain) ; the other four groups were fed a mix of 14% of corn oil and 58% of each one of the same starches under study. No signiÐcant di †erences were found in liver weight or fat digestibility among the groups of study. SigniÐcant di †erences were found on the starches digestibility, the green plantain starch being the one with the lowest digestibility (83È97%). The statistical di †erences showed an interaction between the starch and oil that a †ects the starch present in faeces and the starch digestibility. The evaluation of the blood parameters (cholesterol and triglycerides) showed signiÐcant di †erences when di †erent starches were fed, but no so, when oils were changed. Animals that were fed manioc starch showed a higher concentration of cholesterol and triglycerides (244È150 mg dl~1), while animals that ingested green plantain starch showed the lowest concentration (93È 150 mg dl~1). Our results suggest that the levels of cholesterol in rats was probably inÑuenced by the digestibility of the starches present on the diet. The statistical analysis showed a high interaction starch vs oil over plasmatic triglycerides concentration. The green plantain starch has the same e †ect as some of the resistant starches.