Placental protein 17b overexpression in human uterine cervical cancer

✍ Scribed by Gábor N. Than; Balázs Sümegi; György Szekeres; Szabolcs Bellyei; Nándor G. Than; Andras Szigeti; Hans Bohn

• Book ID: 104455944
• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 457 KB
• Volume: 28
• Category: Article
• ISSN: 1341-8076
• DOI: 10.1046/j.1341-8076.2002.00003.x

✦ Synopsis

Abstract

We found overexpression of placental protein 17b (PP17b), cloned by us, in human squamous cervical carcinomas. Patients’ PP17b serum levels were elevated and declined after surgery. Healthy cervical epithelium was PP17 negative; in cervical intraepithelial neoplasia and carcinoma, basal‐type cells were negative, but squamous‐type cells were positive, for PP17. In HeLa cells, expression of PP17b correlated with cell differentiation and apoptosis.