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PKC-dependent phosphorylation of p27 at T198 contributes to p27 stabilization and cell cycle arrest

โœ Scribed by De Vita, Fernanda; Riccardi, Miriam; Malanga, Donatella; Scrima, Marianna; De Marco, Carmela; Viglietto, Giuseppe

Book ID
118191344
Publisher
Landes Bioscience
Year
2012
Tongue
English
Weight
965 KB
Volume
11
Category
Article
ISSN
1538-4101

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## Abstract The __tuberous sclerosis complex 2__ (__Tsc2__) gene product, tuberin, acts as a negative regulator of mTOR signaling, and loss of tuberin function leads to tumors of the brain, skin, kidney, heart, and lungs. Previous studies have shown that loss of tuberin function affects the stabili