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PKC-Dependent Activation of FAK and Src Induces Tyrosine Phosphorylation of Cas and Formation of Cas–Crk Complexes

✍ Scribed by Pamela J. Bruce-Staskal; Amy H. Bouton


Book ID
115603926
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
171 KB
Volume
264
Category
Article
ISSN
0014-4827

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FAK regulates tyrosine phosphorylation o
✍ Shyamali Roy; Paul J. Ruest; Steven K. Hanks 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 337 KB

## Abstract FAK (focal adhesion kinase) is a nonreceptor protein‐tyrosine kinase activated by tyrosine phosphorylation following integrin‐mediated cell adhesion. Oncogenic Src promotes enhanced and deregulated FAK tyrosine phosphorylation which has been proposed to contribute to altered cell growth