PK-PD-Relationship of Apomorphine in Patients with Parkinson's Disease
✍ Scribed by Harder, S.; Baas, H.; Röger, S.; Demisch, L.
- Book ID
- 110019762
- Publisher
- Nature Publishing Group
- Year
- 1996
- Tongue
- English
- Weight
- 116 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0009-9236
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📜 SIMILAR VOLUMES
We tested a novel preparation of a sublingual apomorphine hydrochloride tablet (APO) in 10 patients with advanced Parkinson's disease complicated by motor fluctuations. After a dose titration, patients took either 40 mg APO three times per day alternating with levodopa doses (eight patients) or six
## Abstract A new formulation of a sublingual tablet with 10 mg apomorphine was examined in 13 patients with Parkinson's disease. Vitamin C (250 mg) was added sublingually to lower the salivary pH. Four patients received sublingual apomorphine and nine received sublingual apomorphine as well as vit