lontophoretic Delivery of Apomorphine II: An In Vivo Study in Patients with Parkinson's Disease
✍ Scribed by Ronald van der Geest; Teus van Laar; Josy M. Gubbens-Stibbe; Harry E. Boddé; Meindert Danhof
- Book ID
- 110309224
- Publisher
- Springer US
- Year
- 1997
- Tongue
- English
- Weight
- 657 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0724-8741
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## Abstract A new formulation of a sublingual tablet with 10 mg apomorphine was examined in 13 patients with Parkinson's disease. Vitamin C (250 mg) was added sublingually to lower the salivary pH. Four patients received sublingual apomorphine and nine received sublingual apomorphine as well as vit
## Abstract The pharmacokinetics and clinical effects of apomorphine after rectal administration were determined in five patients with idiopathic Parkinson's disease (PD). Three different pharmaceutical formulations were tested: a rectal solution of apomorphine (10 or 15 mg), a gelatin suppository