𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Piperidine-mediated synthesis of thiazolyl chalcones and their derivatives as potent antimicrobial agents

✍ Scribed by P. Venkatesan; T. Maruthavanan

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
107 KB
Volume
48
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A series of new thiazolyl chalcones, 1‐[2‐amino‐4‐methyl‐1, 3‐thiazol‐5‐yl]‐3‐aryl‐prop‐2‐en‐1‐one were prepared by piperidine mediated Claisen‐Schmidt condensation of thiazolyl ketone with substituted aromatic aldehyde. These chalcones on cyclization gave 2‐amino‐6‐(2‐amino‐4‐methyl‐1,3‐thiazol‐5‐yl)‐4‐aryl‐4H‐pyridine‐3‐carbonitrile and 2‐amino‐6‐(2‐amino‐4‐methyl‐1,3‐thiazol‐5‐yl)‐4‐aryl‐4H‐pyran‐3‐carbonitrile. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents. The most active antibacterial agent was 2‐amino‐6‐(2‐amino‐4‐methyl‐1,3‐thiazol‐5‐yl)‐4‐(4‐chlorophenyl)‐4H‐pyran‐3‐carbonitrile while 2‐amino‐6‐(2‐amino‐4‐methyl‐1,3‐thiazol‐5‐yl)‐4‐(4‐methoyphenyl)‐4H‐pyran‐3‐carbonitrile appeared to be the most active antifungal agent. J. Heterocyclic Chem., (2011).

📜 SIMILAR VOLUMES

Piperidine mediated synthesis of n-heter
Piperidine mediated synthesis of n-heterocyclic chalcones and their antibacterial activity
✍ P. Venkatesan; S. Sumathi 📂 Article 📅 2009 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 80 KB

## Abstract magnified image The chalcones 1‐(2′‐hydroxy‐aryl)‐3‐(1‐indol‐3‐yl)‐prop‐2‐en‐1‐one **(3)** and 1‐(2′‐hydroxy‐aryl)‐3‐(2‐chloroquinolin‐3‐yl)‐prop‐2‐en‐1‐one **(6)** were synthesised by piperidine mediated condensation of an ethanolic solution of an __o__‐hydroxyacetophenone **(1)** wit

Synthesis of Novel Quinazoline Derivativ
Synthesis of Novel Quinazoline Derivatives as Antimicrobial Agents
✍ A. A. Aly 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 469 KB 👁 1 views

## Abstract Quinazoline isothiocyanate 1 reacts with various nucleophiles (nitrogen nucleophiles, oxygen nucleophiles and sulphur nucleophiles) to afford heterocyclic systemes 2–13. Also, the [4 + 2] cycloaddition reaction of 1 with phenyl isocyanate, benzylidene aryl amine and cinnamic acid deriva