Piperidine mediated synthesis of n-heterocyclic chalcones and their antibacterial activity

✍ Scribed by P. Venkatesan; S. Sumathi

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2009
• Tongue: English
• Weight: 80 KB
• Volume: 47
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.268

✦ Synopsis

Abstract

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The chalcones 1‐(2′‐hydroxy‐aryl)‐3‐(1‐indol‐3‐yl)‐prop‐2‐en‐1‐one (3) and 1‐(2′‐hydroxy‐aryl)‐3‐(2‐chloroquinolin‐3‐yl)‐prop‐2‐en‐1‐one (6) were synthesised by piperidine mediated condensation of an ethanolic solution of an o‐hydroxyacetophenone (1) with corresponding heteroaryl‐3‐carboxaldehyde. The structures have been established on the basis of elemental (C, H, N) analysis, UV, IR, ^1^H NMR spectral data. The compounds 3 and 6 were screened for antimicrobial activities against a variety of bacterial agents. J. Heterocyclic Chem., 2010.