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Pilot-scale process sensitivity studies for the scaleup of a fungal fermentation for the production of pneumocandins

✍ Scribed by D. J. Pollard; T. F. Kirschner; D. Hernandez; G. Hunt; R. Olewinski; P. M. Salmon

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
213 KB
Volume
78
Category
Article
ISSN
0006-3592

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Manganese peroxidase (MnP) production was performed in a airlift bioreactor in which Phanerochaete chrysosporium I-1512, an MnP hypersecretory strain, was immobilized on a stainless steel mesh. Production was scaled up from a 2.5-L bench scale to a 100-L bioreactor. The yield of MnP was increased 2-